Discover Why You Have

Pain that doesn’t resolve is not structural — it is chemical. Unresolved inflammation saturates tissue and lowers your pain threshold systemically. Your cytokine genetics determine how amplified that signal becomes. The pain is real. The reason it persists is written in your biology.

Cognitive clarity requires clean neurochemistry and resolved neuroinflammation. Your MTHFR and FUT2 variants govern how efficiently your brain produces neurotransmitters. Brain fog is not a mood — it is a measurable biological state.

Fatigue that sleep doesn’t resolve is your mitochondria operating under chronic inflammatory suppression. Your PGC1A variant governs energy production. Your HbA1c reflects the glycaemic instability starving your cells. You are not lazy. Your energy systems are overwhelmed.

Chronic stress is a dysregulated HPA axis running on inherited stress-response architecture built for acute threats, not sustained modern pressure. Your CYP1A2 variant governs how caffeine loads that axis daily. Your stress response is genetic. So is its resolution.

NSAIDs (Ibuprofen, Nurofen, Voltarol, Naproxen) suppress the pain signal and reduce measurable inflammation — temporarily. The root cause remains entirely untouched. Your biology learns nothing. The trigger continues.

Chronic NSAID use degrades the gut mucosal lining — the very barrier that protects your bloodstream from inflammatory signals. This is the tax your gut pays for the pain relief you feel.

A compromised gut barrier allows bacterial endotoxins into systemic circulation — driving the very neuroinflammation that makes the pain worse. You take more painkillers. The cycle deepens.

Whether your immune system carries structural variants that predispose it to react to gluten or struggle to digest lactose — not as acquired sensitivity, but as inherited biological architecture.

How rapidly your liver clears caffeine and how sensitively your nervous system responds. Slow metabolisers accumulate it — producing anxiety, disrupted sleep, and elevated cortisol long after the cup has gone.

Your FUT2 secretor status — the single most influential host genetic determinant of gut microbiome composition. Non-secretors (1 in 5) are structurally disadvantaged in maintaining diversity and B12 absorption regardless of diet.

Whether your renin-angiotensin system carries variants making you genetically salt-sensitive. For those with ACE and AGT variants, dietary sodium is a genuine therapeutic lever — not a general lifestyle recommendation.

Your Phase II glutathione conjugation capacity. The GSTM1 deletion is present in approximately 50% of the population — significantly reducing the ability to neutralise reactive compounds generated daily by normal metabolism.

The genetic architecture governing blood sugar regulation, appetite signalling, fatty acid metabolism, and mitochondrial energy production. How your body converts raw materials into fuel and supports its own recovery mechanisms.

Your cytokine production genetics — the variants setting your baseline inflammatory gain. High-expression genotypes produce disproportionate immune responses to dietary antigens, environmental stressors, and psychological pressure.

Whether your biological clock is structurally early or late phase — and what that means for when your cortisol peaks, when your metabolism is most active, and when your immune system is most capable of resolution.

Half the population has significantly reduced Phase II detoxification — a genetic fact standard blood panels never reveal, but that directly governs toxic load accumulation and oxidative stress burden.

The most clinically impactful methylation variant — affecting folate metabolism, homocysteine regulation, neurotransmitter production, and which form of B-vitamins will actually work for that individual.

One in five people carry a variant that structurally compromises B12 absorption and microbiome diversity — regardless of diet or supplementation at standard doses. Population-level advice simply does not apply to them.

Finger-prick lancets, collection cards, prepaid return. Morning baseline. Under five minutes.

Simple cheek swab for the DNA panel. One sample, collected once. Your genome does not change — this result is yours for life.

hsCRP, Cortisol, DHEA-S, Vitamin D, Ferritin, Active B12, HbA1c. UKAS accredited laboratory. Results in 5–7 days of receipt.

Analysis across all nine domains. Ancestral biological patterns decoded and explained in plain language.

Your Baseline Inflamatrix Score alongside your genetic profile. Blood and DNA interpreted together — a map you can act on.

One-to-one with Matt Burden DC — 24 years clinical experience, GCC-registered, LifeCode Gx qualified. Walk through your results and identify your highest-leverage priorities.